Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells.
نویسندگان
چکیده
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.
منابع مشابه
Bilateral Entry and Release of Middle East Respiratory Syndrome-Coronavirus Induces 1 Profound Apoptosis of Human Bronchial Epithelial Cells
24 The newly emerged MERS-CoV infects human bronchial epithelial Calu-3 cells. Unlike 25
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ورودعنوان ژورنال:
- Journal of virology
دوره 87 17 شماره
صفحات -
تاریخ انتشار 2013